EcoR1 Capital, LLC — 13F Holdings

2026 Q1  ·  41 Positions

2026 Q1 Portfolio Activity

In 2026 Q1, EcoR1 Capital, LLC maintained a portfolio of 41 distinct positions. The most significant new addition was AKTIS ONCOLOGY INC, now representing 3.66% of the total fund value. They heavily accumulated shares in CENTESSA PHARMACEUTICALS PLC, increasing the position by 92.6%. The fund also reduced its exposure to CENTESSA PHARMACEUTICALS PLC by 86.8%.
Position History hover any row below to update
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EcoR1 Capital, LLC San Francisco, CA Hedge Fund AUM $2,340M
PCA Score Concentration Risk
Risk ENB
Total Positions
41
Quarter
2026 Q1
Top Holding
ZYME (24.4%)
Top 10 Concentration
88.9%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-41 of 41

EcoR1 Capital, LLC Full Holdings List — 2026 Q1

Stock History Sector / Type Port % Prev % Rank / Prev Conviction
Freshness
Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
ZYME
ZYMEWORKS INC
Healthcare 24.41% 27.44% #1
Prev: #1
7.0
no change no change
P
S
22,970,388 $575,178,516 2022 Q4 13F Filing 2026-03-31 2026-05-15
ANAB
ANAPTYSBIO INC
Healthcare 18.55% 17.33% #2
Prev: #2
6.5
no change no change
P
S
7,880,094 $437,030,013 2019 Q4 13F Filing 2026-03-31 2026-05-15
JAZZ
JAZZ PHARMACEUT...
Healthcare 13.69% 13.16% #3
Prev: #3
6.0
no change no change
P
S
1,706,469 $322,607,964 2023 Q2 13F Filing 2026-03-31 2026-05-15
CNTA
CENTESSA PHARMA...
Healthcare 10.11% 3.53% #4 1
Prev: #5
7.5
2,885,000 92.6%
P
S
6,000,000 $238,320,000 2021 Q2 13F Filing 2026-03-31 2026-05-15
CRNX
CRINETICS PHARM...
Healthcare 6.61% 9.06% #5 1
Prev: #4
4.1
no change no change
P
S
4,288,120 $155,744,518 2020 Q1 13F Filing 2026-03-31 2026-05-15
N/A
AKTIS ONCOLOGY ...
Unknown 3.66% #6
Prev: #—
5.0
4,824,469
NEW
4,824,469 $86,309,750 13F Filing 2026-03-31 2026-05-15
ORIC
ORIC PHARMACEUT...
Healthcare 3.62% 2.50% #7 2
Prev: #9
2.4
no change no change
P
S
6,728,116 $85,245,230 2020 Q2 13F Filing 2026-03-31 2026-05-15
CGON
CG ONCOLOGY INC
Healthcare 3.17% 1.45% #8 6
Prev: #14
3.8
330,000 42.7%
P
S
1,102,000 $74,583,360 2025 Q4 13F Filing 2026-03-31 2026-05-15
CRSP
CRISPR THERAPEU...
Healthcare 2.80% 3.31% #9 3
Prev: #6
2.1
no change no change
P
S
1,389,276 $66,087,859 2018 Q3 13F Filing 2026-03-31 2026-05-15
ETON
ETON PHARMACEUT...
Healthcare 2.27% 1.56% #10 3
Prev: #13
2.9
141,394 7.0%
P
S
2,171,938 $53,603,430 2024 Q3 13F Filing 2026-03-31 2026-05-15
GLPG
GALAPAGOS NV
Healthcare 2.12% 2.47% #11 1
Prev: #10
1.8
no change no change
P
S
1,667,119 $50,013,570 2015 Q4 13F Filing 2026-03-31 2026-05-15
XNCR
XENCOR INC
Healthcare 1.12% 2.26% #12 1
Prev: #11
0.4
-1,068,112 -32.9%
P
S
2,183,000 $26,326,980 2016 Q2 13F Filing 2026-03-31 2026-05-15
NGNE
NEUROGENE INC
Healthcare 1.09% 1.19% #13 3
Prev: #16
1.4
no change no change
P
S
1,271,342 $25,630,255 2023 Q4 13F Filing 2026-03-31 2026-05-15
BBOT
BRIDGEBIO ONCOL...
Healthcare 1.07% 1.60% #14 2
Prev: #12
1.4
no change no change
P
S
2,823,126 $25,266,978 2025 Q3 13F Filing 2026-03-31 2026-05-15
MBX
MBX BIOSCIENCES...
Healthcare 0.98% 3.04% #15 8
Prev: #7
0.4
-1,346,604 -63.4%
P
S
777,000 $23,193,450 2024 Q3 13F Filing 2026-03-31 2026-05-15
RLAY
RELAY THERAPEUT...
Healthcare 0.80% #16
Prev: #—
3.8
1,904,762
NEW
1,904,762 $18,952,382 2020 Q3 13F Filing 2026-03-31 2026-05-15
CNTA
CENTESSA PHARMA...
CALL
CALL Option 0.69% #17
Prev: #—
3.8
410,800
NEW
410,800 $16,316,976 2021 Q2 13F Filing 2026-03-31 2026-05-15
ZBIO
ZENAS BIOPHARMA...
Healthcare 0.66% 1.30% #18 3
Prev: #15
1.3
no change no change
P
S
789,500 $15,434,725 2025 Q4 13F Filing 2026-03-31 2026-05-15
ERAS
ERASCA INC
Healthcare 0.62% #19
Prev: #—
3.7
900,000
NEW
900,000 $14,562,000 2021 Q3 13F Filing 2026-03-31 2026-05-15
N/A
EIKON THERAPEUT...
Unknown 0.33% #20
Prev: #—
3.6
732,606
NEW
732,606 $7,750,971 13F Filing 2026-03-31 2026-05-15
REPL
REPLIMUNE GROUP...
Healthcare 0.32% #21
Prev: #—
3.6
1,000,000
NEW
1,000,000 $7,650,000 2024 Q2 13F Filing 2026-03-31 2026-05-15
ZURA
ZURA BIO LTD
Healthcare 0.30% #22
Prev: #—
3.6
1,179,715
NEW
1,179,715 $7,019,304 2026 Q1 13F Filing 2026-03-31 2026-05-15
PHAT
PHATHOM PHARMAC...
Healthcare 0.29% #23
Prev: #—
3.6
625,000
NEW
625,000 $6,943,750 2023 Q2 13F Filing 2026-03-31 2026-05-15
MREO
MEREO BIOPHARMA...
Healthcare 0.19% 0.15% #24 3
Prev: #27
3.1
5,512,389 70.2%
P
S
13,368,855 $4,411,722 2025 Q4 13F Filing 2026-03-31 2026-05-15
STOK
STOKE THERAPEUT...
Healthcare 0.14% #25
Prev: #—
3.6
100,000
NEW
100,000 $3,256,000 2026 Q1 13F Filing 2026-03-31 2026-05-15
PRLD
PRELUDE THERAPE...
Healthcare 0.14% #26
Prev: #—
3.6
947,049
NEW
947,049 $3,238,908 2023 Q2 13F Filing 2026-03-31 2026-05-15
IBIO
IBIO INC
Healthcare 0.13% 0.20% #27 1
Prev: #26
0.1
-645,000 -28.9%
P
S
1,583,000 $3,007,700 2025 Q4 13F Filing 2026-03-31 2026-05-15
N/A
HELIX ACQUISITI...
Unknown 0.09% #28
Prev: #—
3.5
200,000
NEW
200,000 $2,032,000 13F Filing 2026-03-31 2026-05-15
ATRA
ATARA BIOTHERAP...
Healthcare 0.02% 0.47% #29 7
Prev: #22
0.0
-473,590 -82.6%
P
S
99,593 $471,075 2024 Q2 13F Filing 2026-03-31 2026-05-15
SRZNW
SURROZEN INC
Unknown 0.01% 0.00% #30
Prev: #30
1.0
no change no change
P
S
4,444 $129,454 2021 Q3 13F Filing 2026-03-31 2026-05-15
XNCR
XENCOR INC
CALL
CALL Option 0.00% 0.05%
Sold All 😨
(Was: #29)
0.0
-67,500 -100.0%
CLOSED
$— 2016 Q2 13F Filing 2026-03-31 2026-05-15
CAMP
CAMP4 THERAPEUT...
Healthcare 0.00% 0.09%
Sold All 😨
(Was: #28)
0.0
-325,000 -100.0%
CLOSED
$— 2025 Q4 13F Filing 2026-03-31 2026-05-15
EOLS
EVOLUS INC
Healthcare 0.00% 0.20%
Sold All 😨
(Was: #25)
0.0
-675,000 -100.0%
CLOSED
$— 2019 Q4 13F Filing 2026-03-31 2026-05-15
NUVB/WS
NUVATION BIO IN...
Unknown 0.00% 0.39%
Sold All 😨
(Was: #24)
0.0
-963,333 -100.0%
CLOSED
$— 2021 Q1 13F Filing 2026-03-31 2026-05-15
MNKD
MANNKIND CORP
Healthcare 0.00% 0.43%
Sold All 😨
(Was: #23)
0.0
-1,660,000 -100.0%
CLOSED
$— 2025 Q4 13F Filing 2026-03-31 2026-05-15
CGON
CG ONCOLOGY INC
CALL
CALL Option 0.00% 0.55%
Sold All 😨
(Was: #21)
0.0
-292,800 -100.0%
CLOSED
$— 2025 Q4 13F Filing 2026-03-31 2026-05-15
VYGR
VOYAGER THERAPE...
Healthcare 0.00% 0.71%
Sold All 😨
(Was: #20)
0.0
-4,002,847 -100.0%
CLOSED
$— 2021 Q3 13F Filing 2026-03-31 2026-05-15
AQST
AQUESTIVE THERA...
Healthcare 0.00% 0.77%
Sold All 😨
(Was: #19)
0.0
-2,625,000 -100.0%
CLOSED
$— 2025 Q3 13F Filing 2026-03-31 2026-05-15
PCVX
VAXCYTE INC
Healthcare 0.00% 0.94%
Sold All 😨
(Was: #18)
0.0
-450,000 -100.0%
CLOSED
$— 2021 Q4 13F Filing 2026-03-31 2026-05-15
GPCR
STRUCTURE THERA...
Healthcare 0.00% 1.06%
Sold All 😨
(Was: #17)
0.0
-334,380 -100.0%
CLOSED
$— 2025 Q4 13F Filing 2026-03-31 2026-05-15
IMNM
IMMUNOME INC
Healthcare 0.00% 2.78%
Sold All 😨
(Was: #8)
0.0
-2,855,590 -100.0%
CLOSED
$— 2023 Q4 13F Filing 2026-03-31 2026-05-15
Showing 1-41 of 41 holdings

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