SPHERA FUNDS MANAGEMENT LTD. PRAX — PRAXIS PRECISION MEDICINES I

Ownership history in SPHERA FUNDS MANAGEMENT LTD.  ·  15 quarters on record

AI Ownership Summary

SPHERA FUNDS MANAGEMENT LTD. reported PRAXIS PRECISION MEDICINES I (PRAX) in 15 quarterly 13F filings from 2024 Q1 through 2025 Q4. Peak portfolio weight reached 2.28% in 2025 Q4. The latest visible filing shows PRAX at 2.28% of the fund.

This page tracks quarterly shares, estimated market value, portfolio weight, filing dates, and disclosure-aligned stock prices directly from SEC EDGAR 13F filings.

What this PRAX ownership page tells you

This page is designed to answer the real investor question behind a 13F filing: how meaningful was SPHERA FUNDS MANAGEMENT LTD.'s position in PRAXIS PRECISION MEDICINES I, and how did that conviction change over time? You can read the holding window, peak weight, latest reported size, disclosure timing, and quarter-by-quarter changes without piecing the story together from raw SEC rows.

Freshest filing
Latest Reported Filing
2025 Q4

PRAX was reported at 2.28% of portfolio in the most recent visible filing.

High-water mark
Peak Conviction
2.28% in 2025 Q4

Peak weight helps separate a token disclosure from a real conviction holding the fund genuinely cared about.

Time in book
Holding Window
2024 Q1 to 2025 Q4

Longer holding windows often tell a very different story from short-lived tactical trades or one-quarter experiments.

Decision context
Why It Matters
Position size beats headlines

Knowing that a fund owned a stock is useful. Knowing whether it was a 0.20% placeholder or a true high-conviction position is where the signal actually starts.

PRAX stock page SPHERA FUNDS MANAGEMENT LTD. fund profile SPHERA FUNDS MANAGEMENT LTD. full holdings
How SPHERA FUNDS MANAGEMENT LTD. held PRAX — position size vs. price
% of Fund (quarterly)    PRAX price (quarter-end, indexed to 100)    SPY (indexed to 100)    QQQ (indexed to 100)
📋 Quarterly Holdings History 15 quarters  ▾
Quarter Action Sold % After 3M Timing Shares Change Chg % % of Fund Mkt Value Filed Price (Filed)
2025 Q4 REDUCED 30.9% +9.3% ❌ 40,000 -17,901 -30.9% 2.28% $11.8M 2026-02-17 $328.04
2025 Q3 ADDED — — — 57,901 +7,901 +15.8% 0.65% $3.1M 2025-11-14 $186.42
2025 Q3 REDUCED 50.0% +474.7% ❌ 50,000 -50,000 -50.0% 0.56% $2.6M 2025-11-14 $186.42
2025 Q2 REDUCED 8.9% +24.6% ❌ 100,000 -9,757 -8.9% 0.99% $4.2M 2025-08-14 $47.70
2025 Q2 ADDED — — — 109,757 +9,757 +9.8% 1.08% $4.6M 2025-08-14 $47.70
2025 Q1 REDUCED 28.9% +11.0% ❌ 100,000 -40,660 -28.9% 0.87% $3.8M 2025-05-15 $37.20
2025 Q1 ADDED — — — 140,660 +57,660 +69.5% 1.23% $5.3M 2025-05-15 $37.20
2024 Q4 REDUCED 9.4% -50.8% ✅ 83,000 -8,583 -9.4% 1.15% $6.4M 2025-02-14 $90.77
2024 Q4 ADDED — — — 91,583 +51,583 +129.0% 1.27% $7.0M 2025-02-14 $90.77
2024 Q3 REDUCED 23.1% +32.5% ❌ 40,000 -12,000 -23.1% 0.37% $2.3M 2024-11-14 $76.88
2024 Q3 REDUCED 65.9% +32.5% ❌ 52,000 -100,307 -65.9% 0.48% $3.0M 2024-11-14 $76.88
2024 Q3 ADDED — — — 152,307 +77,307 +103.1% 1.39% $8.8M 2024-11-14 $76.88
2024 Q2 REDUCED 73.5% +39.1% ❌ 75,000 -208,424 -73.5% 0.42% $3.1M 2024-08-14 $51.26
2024 Q2 ADDED — — — 283,424 +106,285 +60.0% 1.60% $11.7M 2024-08-14 $51.26
2024 Q1 INITIATED — — — 177,139 — — 1.52% $10.8M 2024-05-15 $44.00

🏢 Other funds also holding PRAX

As of 2026 Q1 — sorted by position size

72 Investment Holdings, LLC 3Y 42.83% Velan Capital Investment Management LP 3Y 20.34% ACUTA CAPITAL PARTNERS, LLC 3Y 7Y 19.3% Cormorant Asset Management, LP 3Y 7Y 14.33% PERCEPTIVE ADVISORS LLC 3Y 7Y 12.83% KVP Capital Advisors, LP 10.32% Vivo Capital, LLC 3Y 7Y 9.11% Lion Point Capital, LP 3Y 7Y 8.57% Ally Bridge Group (NY) LLC 3Y 8.54% B Group, Inc. 7.94%

FAQ About SPHERA FUNDS MANAGEMENT LTD. and PRAX

These are the practical questions this page is built to answer before you even open the full history table.

How long has SPHERA FUNDS MANAGEMENT LTD. reported owning PRAX?

SPHERA FUNDS MANAGEMENT LTD. reported PRAX across 15 quarterly 13F filings, from 2024 Q1 through 2025 Q4.

What was the largest reported PRAX position in SPHERA FUNDS MANAGEMENT LTD.'s portfolio?

The largest reported portfolio weight for PRAX was 2.28% in 2025 Q4.

What is the latest reported PRAX position on this page?

The most recent filing on this page is 2025 Q4, when SPHERA FUNDS MANAGEMENT LTD. reported 40,000 shares, equal to 2.28% of portfolio, with an estimated market value of $11.8M.

What does the chart on this PRAX ownership page compare?

The chart compares SPHERA FUNDS MANAGEMENT LTD.'s quarterly PRAX portfolio weight with the stock's indexed share price, so you can see whether the fund was building, trimming, or holding the position as price moved.

How well did SPHERA FUNDS MANAGEMENT LTD. time their PRAX position?

Based on 13F filing dates vs. subsequent PRAX price moves, SPHERA FUNDS MANAGEMENT LTD. correctly timed 5 out of 14 reported position changes (36%). The annualised alpha on PRAX relative to SPY over the holding period was +167.7%.

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