Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

KARYOPHARM THERAPEUTICS INC (KPTI)

75 + Investors. Track Smart Money conviction in KPTI. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +13
Streak
3Q ▲
Buyers last Q
71%

Smart Money Signals — KPTI

Based on 70 hedge funds · latest filing: 2025 Q4 · updated quarterly

📈

Buying streak — 3 quarters in a row

last 6Q
For 3 consecutive quarters, more hedge funds added KPTI than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🔻

Below peak — only 55% of 3.0Y high

55% of all-time peak
Only 70 funds hold KPTI today versus a peak of 127 funds at 2023 Q2 — just 55% of the maximum. Low institutional ownership can mean the stock is out of favor, but it also means there's a large pool of potential buyers if sentiment turns.
📉

Outflows — 20% fewer funds vs a year ago

fund count last 6Q
17 fewer hedge funds hold KPTI compared to a year ago (-20% decline). When institutions consistently reduce their exposure, it's worth exploring the underlying fundamental reasons driving them away.
🟢

More buyers than sellers — 71% buying

46 buying19 selling
Last quarter: 46 funds were net buyers (24 opened a brand new position + 22 added to an existing one). Only 19 were sellers (8 trimmed + 11 sold completely). A clear majority buying is a strong confirmation signal.
📈

More new buyers each quarter (+16 vs last Q)

new funds entering per quarter
Funds opening a new KPTI position: 5 → 11 → 8 → 24. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.
🔒

64% of holders stayed for 2+ years

■ 64% conviction (2yr+) ■ 23% medium ■ 13% new
45 out of 70 hedge funds have held KPTI for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
💎

Buying through price weakness — shares +169%, value +28%

Value
+27%
Shares
+168%
Last quarter: funds added +169% more shares while total portfolio value only changed +28%. Institutions were buying while the price was falling — a high-conviction accumulation signal. They're deliberately loading up on the dip.
🚀

Acceleration phase — new buyers rushing in

14 → 5 → 11 → 8 → 24 new funds/Q
New funds entering each quarter: 5 → 11 → 8 → 24. The pace of institutional discovery is accelerating sharply. This is the 'hot idea' phase — the thesis is being passed from fund to fund. You are not late — the accumulation wave is still building.
🏛️

Deep conviction — 74% of holders stayed 2+ years

■ 74% veterans ■ 8% 1-2yr ■ 18% new
Of 76 current holders: 56 (74%) have held for over 2 years without selling. These are not momentum buyers — they have lived through drawdowns and stayed. A large veteran base acts as a stabilizing force during selloffs.
📋

Smaller funds dominant — 5% AUM from top-100

5% from top-100 AUM funds
20 of 70 holders rank in the top 100 by AUM, but together hold only 5% of total institutional value. The stock is held primarily by smaller and mid-sized funds.
1.1
out of 10
Low Exit Risk
Exit risk score 1.1/10 — low institutional crowding. Ownership is below peak levels, holder base is relatively sticky, and buying momentum is positive.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — KPTI

In 2025 Q4, 46 hedge funds were net buyers of KPTI (24 opened a new position, 22 added to an existing one), while 19 reduced or exited (8 trimmed, 11 sold completely) — a 71% buyer ratio, indicating clear institutional accumulation. This marks 3 consecutive quarters of net institutional buying — a persistent conviction signal. Net fund flow last quarter: +13 funds (more new holders than closures). Total institutional holders: 70.

Hedge Fund Ownership: KPTI

How many hedge funds hold KPTI — quarterly history vs. share price
Quarterly hedge fund ownership of KPTI vs. share price

Market Analysis: KPTI

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: KPTI

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Is It Too Late to Buy KARYOPHARM THERAPEUTICS INC (KPTI) Based on Hedge Fund 13F Filings?

Signal Freshness measures how much KPTI has moved relative to its sector benchmark (XLV) since the 2026 Q1 13F filing. A stock that has barely outrun its sector is still a relatively fresh entry point — the fund's thesis has not yet been priced in by the broader market.

Since Quarter End March 31, 2026 · 49d ago
KPTI
+40.7%
XLV
-11.8%

KPTI outperformed XLV by +52.5% since March 31, 2026.

Since 13F Filing Date May 15, 2026 · 4d ago
KPTI
-6.9%
XLV
-5.2%

Since the filing became public, KPTI outperformed XLV by -1.7% .

Interpretation: The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference. Learn more →

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

11 top-rated funds 0 high-conviction
Consensus
4.7
/ 10
breadth
×
Elite
0.5
/ 10
conviction
Hedge Fund Positioning: KPTI
2026 Q1 Stats Unlock in 1 days 75 + Investors

Track Smart Money conviction in KPTI. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2025 Q4) Prior (2025 Q3) Change
Funds Holding 75 60 25.0%
13F Shares 9M 4M 168.55%
Total Value $363M $284M 27.88%
New Positions 24 9 +15
Increased Positions 33 14 +19
Closed Positions 11 5 +6
Reduced Positions 11 23 -12
Total Calls 4 4 -
Total Puts 3 3 -
PUT/CALL Ratio 0.75 0.75 Neutral

Statistics: KPTI

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Valuation Measures Data as of: --

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PEG Ratio (5yr expected) --
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Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

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Total Cash (mrq) --
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Institutional Holders (2026 Q1)

75 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in KPTI. Verified SEC 13F-HR filings.

QUARTER:
Top 25 institutional holders of KPTI — 2025 Q4 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Squadron Capital Management LLC 1.53% 750,000 $4.2M
2 Ally Bridge Group (NY) LLC 1.12% 250,000 $1.4M
3 Catalio Capital Management, LP 1.04% 897,709 $5.0M
4 Avidity Partners Management LP 0.87% 463,741 $3.9M
5 Commodore Capital LP 0.63% 1,950,000 $10.9M
6 ACORN CAPITAL ADVISORS, LLC 0.46% 287,826 $1.6M
7 Ikarian Capital, LLC 0.42% 920,000 $5.1M
8 Ikarian Capital, LLC 0.42% 920,000 $5.1M
9 Ikarian Capital, LLC 0.33% 733,435 $4.1M
10 Birchview Capital, LP 0.27% 83,952 $468K
11 DIADEMA PARTNERS LP 0.23% 241,300 $1.3M
12 Boxer Capital Management, LLC 0.22% 302,536 $1.7M
13 Affinity Asset Advisors, LLC 0.14% 500,000 $2.8M
14 RA CAPITAL MANAGEMENT, L.P. 0.11% 1,917,354 $10.7M
15 Soleus Capital Management, L.P. 0.10% 440,000 $2.5M
16 SILVERBACK ASSET MANAGEMENT LLC 0.08% 100,000 $557K
17 Eversept Partners, LP 0.08% 276,174 $1.5M
18 ADAR1 Capital Management, LLC 0.07% 205,200 $1.1M
19 DAFNA Capital Management LLC 0.06% 45,800 $255K
20 Tetragon Partners GP Ltd 0.06% 52,984 $295K
21 Tetragon Partners GP Ltd 0.05% 50,000 $278K
22 SILVERBACK ASSET MANAGEMENT LLC 0.05% 65,000 $362K
23 Velan Capital Investment Management LP 0.05% 15,000 $84K
24 ADAR1 Capital Management, LLC 0.04% 136,736 $762K
25 Caption Management, LLC 0.04% 1,086,900 $6.1M
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — KARYOPHARM THERAPEUTICS INC (KPTI)

What does the Smart Money Trend signal show for KPTI?

Buying streak — 3 quarters in a row: For 3 consecutive quarters, more hedge funds added KPTI than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for KPTI?

More buyers than sellers — 71% buying: Last quarter: 46 funds were net buyers (24 opened a brand new position + 22 added to an existing one). Only 19 were sellers (8 trimmed + 11 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for KPTI holders?

Smaller funds dominant — 5% AUM from top-100: 20 of 70 holders rank in the top 100 by AUM, but together hold only 5% of total institutional value. The stock is held primarily by smaller and mid-sized funds.

How long have hedge funds held KPTI?

64% of holders stayed for 2+ years: 45 out of 70 hedge funds have held KPTI for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Is it too late to buy KARYOPHARM THERAPEUTICS INC (KPTI) following the 2026 Q1 hedge fund 13F filings?

As of today, KPTI has moved -6.9% since the 2026 Q1 13F filing date (May 15, 2026), compared to -5.2% for the XLV sector ETF — an outperformance of -1.7%. Since the quarter end (March 31, 2026), KPTI has gained +40.7% vs -11.8% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.