Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Karyopharm Therapeutics Inc (KPTI)

94 + Investors. Track Smart Money conviction in KPTI. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +15
Streak
5Q ▲
Buyers last Q
67%

Smart Money Signals — KPTI

Based on 98 hedge funds · latest filing: 2026 Q2 · updated quarterly

📈

Buying streak — 5 quarters in a row

last 6Q
For 5 consecutive quarters, more hedge funds added KPTI than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
📊

High ownership — 86% of 3.0Y peak

86% of all-time peak
98 funds currently hold this stock — 86% of the 3.0-year high of 114 funds (reached 2023 Q3). Ownership is elevated but not yet at maximum concentration. Room to grow, but watch if the trend reverses.
🚀

Fast accumulation — +81% more funds vs a year ago

fund count last 6Q
+44 new funds entered over the past year (+81% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.
🟢

More buyers than sellers — 67% buying

72 buying36 selling
Last quarter: 72 funds were net buyers (35 opened a brand new position + 37 added to an existing one). Only 36 were sellers (16 trimmed + 20 sold completely). A clear majority buying is a strong confirmation signal.
📈

More new buyers each quarter (+6 vs last Q)

new funds entering per quarter
Funds opening a new KPTI position: 8 → 24 → 29 → 35. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.
🔒

62% of holders stayed for 2+ years

■ 62% conviction (2yr+) ■ 10% medium ■ 28% new
61 out of 98 hedge funds have held KPTI for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
💰

Price up while funds trimmed (+56% value, -12% shares)

Value
+56%
Shares
-11%
Last quarter: total value of institutional KPTI holdings rose +56% even though funds reduced share count by 12%. The stock price increased enough to offset the selling. Institutions are quietly trimming into price strength — watch for rotation.
🚀

Acceleration phase — new buyers rushing in

11 → 8 → 24 → 29 → 35 new funds/Q
New funds entering each quarter: 8 → 24 → 29 → 35. The pace of institutional discovery is accelerating sharply. This is the 'hot idea' phase — the thesis is being passed from fund to fund. You are not late — the accumulation wave is still building.
🏛️

Veteran-anchored — 70% veterans vs 20% newcomers

■ 70% veterans ■ 9% 1-2yr ■ 20% new
Entry-cohort mix of 108 holders: 76 (70%) are 2+ year veterans, 10 entered 1–2 years ago, and 22 (20%) joined within the past year. A veteran-weighted cap table skews toward institutional memory over fresh momentum.
✅

Strong quality — 33% AUM from major funds

33% from top-100 AUM funds
27 of 94 holders rank in the top 100 by AUM, accounting for 33% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.
4.0
out of 10
Moderate Exit Risk
Exit risk score 4.0/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — KPTI

In 2026 Q2, 72 hedge funds were net buyers of KPTI (35 opened a new position, 37 added to an existing one), while 36 reduced or exited (16 trimmed, 20 sold completely) — a 67% buyer ratio, indicating clear institutional accumulation. This marks 5 consecutive quarters of net institutional buying — a persistent conviction signal. 33% of total institutional value in KPTI is held by top-100 AUM funds, reflecting strong institutional quality. Net fund flow last quarter: +15 funds (more new holders than closures). Total institutional holders: 98.

Hedge Fund Ownership: KPTI

How many hedge funds hold KPTI — quarterly history vs. share price
Quarterly hedge fund ownership of KPTI vs. share price

Market Analysis: KPTI

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: KPTI

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Loading signal freshness…
Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

5 top-rated funds 2 high-conviction
Consensus
3.4
/ 10
breadth
×
Elite
2.3
/ 10
conviction
Hedge Fund Positioning: KPTI
94 + Investors

Track Smart Money conviction in KPTI. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2026 Q2) Prior (2026 Q1) Change
Funds Holding 94 83 13.25%
13F Shares 22M 25M -11.81%
Total Value $207M $133M 56.41%
New Positions 35 29 +6
Increased Positions 31 34 -3
Closed Positions 20 16 +4
Reduced Positions 17 8 +9
Total Calls 7 16 -56.25%
Total Puts 7 7 -
PUT/CALL Ratio 1.0 0.44 Neutral

Statistics: KPTI

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Institutional Holders (2026 Q2)

94 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in KPTI. Verified SEC 13F-HR filings.

QUARTER:
Top 25 KPTI holders by conviction (% of portfolio weight) — 2026 Q2 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Kalehua Capital Management LLC 4.80% 685,644 $6.7M
2 Acorn Capital Advisors, LLC 4.05% 1,518,113 $14.8M
3 Catalio Capital Management, LP 1.73% 940,855 $9.2M
4 Avidity Partners Management LP 1.45% 924,487 $9.0M
5 Tetragon Partners GP Ltd 0.39% 250,300 $2.4M
6 NEA Management Company, LLC 0.35% 576,780 $5.6M
7 Silverarc Capital Management, LLC 0.30% 297,460 $2.9M
8 Boxer Capital Management, LLC 0.22% 302,536 $3.0M
9 Birchview Capital, LP 0.20% 42,952 $420K
10 Ra Capital Management, L.P. 0.16% 1,917,354 $18.7M
11 Soleus Capital Management, L.P. 0.15% 440,000 $4.3M
12 Eversept Partners, LP 0.14% 276,174 $2.7M
13 Affinity Asset Advisors, LLC 0.14% 312,500 $3.1M
14 Velan Capital Investment Management LP 0.12% 20,000 $195K
15 Silverback Asset Management LLC 0.11% 100,000 $977K
16 Ghisallo Capital Management LLC 0.10% 500,000 $4.9M
17 DLD Asset Management, LP 0.07% 101,500 $990K
18 DLD Asset Management, LP 0.05% 80,100 $781K
19 Silverback Asset Management LLC 0.03% 30,000 $293K
20 Brevan Howard Capital Management LP 0.02% 309,817 $3.0M
21 Adage Capital Partners GP, L.L.C. 0.02% 1,521,322 $14.9M
22 J. Goldman & Co LP 0.02% 67,600 $660K
23 J. Goldman & Co LP 0.02% 67,500 $659K
24 China Universal Asset Management Co., Ltd. 0.01% 25,000 $244K
25 Caption Management, LLC 0.01% 285,700 $2.8M
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Karyopharm Therapeutics Inc (KPTI)

What does the Smart Money Trend signal show for KPTI?

Buying streak — 5 quarters in a row: For 5 consecutive quarters, more hedge funds added KPTI than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for KPTI?

More buyers than sellers — 67% buying: Last quarter: 72 funds were net buyers (35 opened a brand new position + 37 added to an existing one). Only 36 were sellers (16 trimmed + 20 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for KPTI holders?

Strong quality — 33% AUM from major funds: 27 of 94 holders rank in the top 100 by AUM, accounting for 33% of total institutional value held. A meaningful share of the ownership value comes from the most well-resourced institutions.

How long have hedge funds held KPTI?

62% of holders stayed for 2+ years: 61 out of 98 hedge funds have held KPTI for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.

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