Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

Pyxis Oncology Inc (PYXS)

81 + Investors. Track Smart Money conviction in PYXS. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +5
Streak
1Q ▲
Buyers last Q
60%

Smart Money Signals — PYXS

Based on 78 hedge funds · latest filing: 2025 Q4 · updated quarterly

📈

Buying streak — 1 quarter in a row

last 6Q
For 1 consecutive quarter, more hedge funds added PYXS than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
📊

High ownership — 81% of 3.0Y peak

81% of all-time peak
78 funds currently hold this stock — 81% of the 3.0-year high of 96 funds (reached 2024 Q4). Ownership is elevated but not yet at maximum concentration. Room to grow, but watch if the trend reverses.
📉

Outflows — 19% fewer funds vs a year ago

fund count last 6Q
18 fewer hedge funds hold PYXS compared to a year ago (-19% decline). When institutions consistently reduce their exposure, it's worth exploring the underlying fundamental reasons driving them away.
🟢

More buyers than sellers — 60% buying

49 buying33 selling
Last quarter: 49 funds were net buyers (22 opened a brand new position + 27 added to an existing one). Only 33 were sellers (16 trimmed + 17 sold completely). A clear majority buying is a strong confirmation signal.
📈

More new buyers each quarter (+8 vs last Q)

new funds entering per quarter
Funds opening a new PYXS position: 14 → 15 → 14 → 22. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.
🔒

47% of holders stayed for 2+ years

■ 47% conviction (2yr+) ■ 28% medium ■ 24% new
37 out of 78 hedge funds have held PYXS for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
💎

Buying through price weakness — shares +13%, value -4%

Value
-4%
Shares
+13%
Last quarter: funds added +13% more shares while total portfolio value only changed -4%. Institutions were buying while the price was falling — a high-conviction accumulation signal. They're deliberately loading up on the dip.
📈

Growing discovery — still being found

23 → 14 → 15 → 14 → 22 new funds/Q
New funds entering each quarter: 14 → 15 → 14 → 22. A growing number of institutions are discovering PYXS each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.
🏛️

Deep conviction — 56% of holders stayed 2+ years

■ 56% veterans ■ 16% 1-2yr ■ 28% new
Of 81 current holders: 45 (56%) have held for over 2 years without selling. These are not momentum buyers — they have lived through drawdowns and stayed. A large veteran base acts as a stabilizing force during selloffs.
📋

Smaller funds dominant — 1% AUM from top-100

1% from top-100 AUM funds
19 of 78 holders rank in the top 100 by AUM, but together hold only 1% of total institutional value. The stock is held primarily by smaller and mid-sized funds.
2.7
out of 10
Low Exit Risk
Exit risk score 2.7/10 — low institutional crowding. Ownership is below peak levels, holder base is relatively sticky, and buying momentum is positive.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Institutional Sentiment Summary — PYXS

In 2025 Q4, 49 hedge funds were net buyers of PYXS (22 opened a new position, 27 added to an existing one), while 33 reduced or exited (16 trimmed, 17 sold completely) — a 60% buyer ratio, indicating clear institutional accumulation. Net fund flow last quarter: +5 funds (more new holders than closures). Total institutional holders: 78.

Hedge Fund Ownership: PYXS

How many hedge funds hold PYXS — quarterly history vs. share price
Quarterly hedge fund ownership of PYXS vs. share price

Market Analysis: PYXS

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: PYXS

Healthcare Biotechnology

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Smart Money Signal ?
Limited Smart Money Interest

No strong consensus or elite conviction detected among institutional holders.

15 top-rated funds 2 high-conviction
Consensus
5.2
/ 10
breadth
×
Elite
1.6
/ 10
conviction
Hedge Fund Positioning: PYXS
2026 Q1 Stats Unlock in 7 days 81 + Investors

Track Smart Money conviction in PYXS. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2025 Q4) Prior (2025 Q3) Change
Funds Holding 81 74 9.46%
13F Shares 31M 27M 13.47%
Total Value $596M $620M -3.96%
New Positions 22 14 +8
Increased Positions 29 10 +19
Closed Positions 17 15 +2
Reduced Positions 18 32 -14
Total Calls 2 1 100.0%
Total Puts 1 0 100%
PUT/CALL Ratio 0.5 0.0 Bullish

Statistics: PYXS

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Valuation Measures Data as of: --

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PEG Ratio (5yr expected) --
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Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

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Institutional Holders (2026 Q1)

81 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in PYXS. Verified SEC 13F-HR filings.

Top 25 institutional holders of PYXS — 2025 Q4 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 PFIZER INC 3.86% 7,032,770 $9.2M
2 Atle Fund Management AB 0.52% 197,036 $1.6M
3 Decheng Capital LLC 0.07% 326,810 $477K
4 UNIVERSITY OF CHICAGO 0.02% 48,731 $71K
5 J. Derek Lewis & Associates Inc. 0.01% 53,000 $61K
6 PACES FERRY WEALTH ADVISORS, LLC 0.01% 11,440 $17K
7 Maia Wealth LLC 0.01% 21,277 $31K
8 Catalyst Funds Management Pty Ltd 0.01% 20,400 $30K
9 HAGER INVESTMENT MANAGEMENT SERVICES, LLC 0.00% 5,000 $7K
10 Winthrop Capital Management, LLC 0.00% 6,000 —
11 NewEdge Wealth, LLC 0.00% 116,006 $169K
12 China Universal Asset Management Co., Ltd. 0.00% 11,049 $16K
13 ACADIAN ASSET MANAGEMENT LLC 0.00% 144,256 —
14 Cornerstone Financial Management LLC 0.00% 172 —
15 Physician Wealth Advisors, Inc. 0.00% 943 $1K
16 VANGUARD FIDUCIARY TRUST CO 0.00% 300,897 $439K
17 VANGUARD CAPITAL MANAGEMENT LLC 0.00% 2,033,510 $3.0M
18 COMMONWEALTH EQUITY SERVICES, LLC 0.00% 34,755 $51K
19 STIFEL FINANCIAL CORP 0.00% 50,537 $74K
20 JANE STREET GROUP, LLC 0.00% 304,459 $445K
21 UBS Group AG 0.00% 254,124 $371K
22 GF FUND MANAGEMENT CO. LTD. 0.00% 1,316 $2K
23 BlackRock, Inc. 0.00% 788,839 $1.2M
24 LPL Financial LLC 0.00% 33,554 $49K
25 FEDERATED HERMES, INC. 0.00% 3,181 $5K
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — Pyxis Oncology Inc (PYXS)

What does the Smart Money Trend signal show for PYXS?

Buying streak — 1 quarter in a row: For 1 consecutive quarter, more hedge funds added PYXS than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for PYXS?

More buyers than sellers — 60% buying: Last quarter: 49 funds were net buyers (22 opened a brand new position + 27 added to an existing one). Only 33 were sellers (16 trimmed + 17 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for PYXS holders?

Smaller funds dominant — 1% AUM from top-100: 19 of 78 holders rank in the top 100 by AUM, but together hold only 1% of total institutional value. The stock is held primarily by smaller and mid-sized funds.

How long have hedge funds held PYXS?

47% of holders stayed for 2+ years: 37 out of 78 hedge funds have held PYXS for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.