SIONNA THERAPEUTICS INC (SION): Hedge Fund Ownership & Smart Money Signals (Q1 2026)

Q: Is it too late to buy SIONNA THERAPEUTICS INC (SION) following the 2026 Q1 hedge fund 13F filings?

As of today, SION has moved -16.7% since the 2026 Q1 13F filing date (May 15, 2026), compared to +5.2% for the XLV sector ETF — an outperformance of -21.9%. Since the quarter end (March 31, 2026), SION gained -14.9% vs +4.1% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

SIONNA THERAPEUTICS INC (SION)

119 + Investors. Track Smart Money conviction in SION. See who's accumulating, reducing, or initiating positions.

Smart Money Signals — SION

Based on 119 hedge funds · latest filing: 2026 Q1 · updated quarterly

📈

Buying streak — 5 quarters in a row

last 6Q

For 5 consecutive quarters, more hedge funds added SION than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

🏔️

At the ownership peak (100% of max)

100% of all-time peak

119 hedge funds hold SION right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.

🚀

Fast accumulation — +153% more funds vs a year ago

fund count last 6Q

+72 new funds entered over the past year (+153% YoY). That's a rapid rush of institutional money. Fast accumulation often signals a major thesis — but it also means the stock could fall quickly if that thesis breaks.

🟢

More buyers than sellers — 62% buying

69 buying42 selling

Last quarter: 69 funds were net buyers (31 opened a brand new position + 38 added to an existing one). Only 42 were sellers (30 trimmed + 12 sold completely). A clear majority buying is a strong confirmation signal.

➡️

Steady new buyers — ~31 new funds per quarter

new funds entering per quarter

Funds opening this position for the first time: 26 → 19 → 30 → 31. A stable flow of new institutional buyers suggests ongoing interest without signs of either acceleration or slowdown.

🔄

Mostly new holders — 54% entered in last year

■ 4% conviction (2yr+) ■ 42% medium ■ 54% new

Only 5 funds (4%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.

📈

Growing discovery — still being found

46 → 26 → 19 → 30 → 31 new funds/Q

New funds entering each quarter: 26 → 19 → 30 → 31. A growing number of institutions are discovering SION each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.

🌱

Early stage — 93% of holders entered in last year

■ 7% veterans ■ 0% 1-2yr ■ 93% new

Of 119 current holders: 111 (93%) entered in the past year, only 8 (7%) are 2+ year veterans. This is an early-phase institutional idea — still being discovered. High upside potential if the thesis plays out, but thin conviction base.

📋

Smaller funds dominant — 13% AUM from top-100

13% from top-100 AUM funds

32 of 119 holders rank in the top 100 by AUM, but together hold only 13% of total institutional value. The stock is held primarily by smaller and mid-sized funds.

5.8

out of 10

Moderate Exit Risk

Exit risk score 5.8/10 — some crowding factors present, but no critical concentration. Watch ownership trend over the next 1–2 quarters for direction.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Metric	All 13F Filers (2026 Q1)	Prior (2025 Q4)	Change
Funds Holding	119	100	19.0%
13F Shares	44M	44M	-0.04%
Total Value	$1.73B	$1.77B	-2.43%
New Positions	31	30	+1
Increased Positions	38	38	-
Closed Positions	12	7	+5
Reduced Positions	30	20	+10
Total Calls	0	0	-
Total Puts	0	0	-
PUT/CALL Ratio	0.0	0.0	Bullish

Metric

All 13F Filers (2026 Q1)

Prior (2025 Q4)

Change

Funds Holding

119

100

19.0%

13F Shares

44M

-0.04%

Total Value

$1.73B

$1.77B

-2.43%

New Positions

Increased Positions

Closed Positions

Reduced Positions

+10

Total Calls

Total Puts

PUT/CALL Ratio

0.0

Bullish

Institutional Holders (2026 Q1)

119 + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in SION. Verified SEC 13F-HR filings.

QUARTER:

FILTER:All New Added To Reduced No Change | Overweight >5%

Top 25 institutional holders of SION — 2026 Q1 · Source: SEC Form 13F
#	Investor	% of Portfolio	Shares	Mkt Value
1	Enavate Sciences GP, LLC	28.26%	2,478,030	$99.3M
2	Atlas Venture Life Science Advisors, LLC	15.20%	2,995,602	$120.1M
3	TPG GP A, LLC	7.08%	6,494,962	$260.4M
4	Kalehua Capital Management LLC	6.66%	197,072	$7.9M
5	RA CAPITAL MANAGEMENT, L.P.	4.21%	9,905,045	$397.1M
6	SUPERSTRING CAPITAL MANAGEMENT LP	4.04%	141,024	$5.7M
7	GordonMD Global Investments LP	3.80%	136,000	$5.5M
8	ORBIMED ADVISORS LLC	2.81%	3,530,702	$141.5M
9	Ishara Investments LP	1.87%	49,200	$2.0M
10	Sio Capital Management, LLC	1.69%	294,340	$11.8M
11	Artia Global Partners LP	0.96%	119,741	$4.8M
12	PERCEPTIVE ADVISORS LLC	0.52%	658,439	$26.4M
13	Soleus Capital Management, L.P.	0.48%	293,500	$11.8M
14	DEERFIELD MANAGEMENT COMPANY, L.P.	0.46%	970,590	$38.9M
15	Rhenman & Partners Asset Management AB	0.43%	87,500	$3.5M
16	EVENTIDE ASSET MANAGEMENT, LLC	0.43%	645,530	$25.9M
17	VIKING GLOBAL INVESTORS LP	0.36%	3,195,181	$128.1M
18	Siren, L.L.C.	0.33%	300,000	$12.0M
19	STEMPOINT CAPITAL LP	0.28%	36,540	$1.5M
20	Rock Springs Capital Management LP	0.23%	99,429	$4.0M
21	AlphaCentric Advisors LLC	0.19%	4,818	$193K
22	SILVERARC CAPITAL MANAGEMENT, LLC	0.16%	39,417	$1.6M
23	SEVEN GRAND MANAGERS, LLC	0.13%	50,000	$2.0M
24	VARCOV Co.	0.10%	6,571	$263K
25	Integral Health Asset Management, LLC	0.10%	50,000	$2.0M

Investor	Ownership History	% of Portfolio	Prev %	Rank	Conviction	Avg Buy Price	13F Score™ 3Y / 7Y	Sell Timing	Shares	Mkt Value	Change	Change %	Source	Quarter	Filed

Frequently Asked Questions — SIONNA THERAPEUTICS INC (SION)

What does the Smart Money Trend signal show for SION?

Buying streak — 5 quarters in a row: For 5 consecutive quarters, more hedge funds added SION than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for SION?

More buyers than sellers — 62% buying: Last quarter: 69 funds were net buyers (31 opened a brand new position + 38 added to an existing one). Only 42 were sellers (30 trimmed + 12 sold completely). A clear majority buying is a strong confirmation signal.

What is the fund quality score for SION holders?

Smaller funds dominant — 13% AUM from top-100: 32 of 119 holders rank in the top 100 by AUM, but together hold only 13% of total institutional value. The stock is held primarily by smaller and mid-sized funds.

How long have hedge funds held SION?

Mostly new holders — 54% entered in last year: Only 5 funds (4%) have held >2 years. The majority of current holders are relatively new to the position. New holders tend to sell faster when prices drop — a shallow conviction base that could amplify any sell-off.

Is it too late to buy SIONNA THERAPEUTICS INC (SION) following the 2026 Q1 hedge fund 13F filings?

As of today, SION has moved -16.7% since the 2026 Q1 13F filing date (May 15, 2026), compared to +5.2% for the XLV sector ETF — an outperformance of -21.9%. Since the quarter end (March 31, 2026), SION has gained -14.9% vs +4.1% for XLV. The stock is tracking its sector benchmark closely. The signal remains fresh and the entry point is still near the fund's implied reference.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

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SIONNA THERAPEUTICS INC (SION)

Smart Money Signals — SION

Buying streak — 5 quarters in a row

At the ownership peak (100% of max)

Fast accumulation — +153% more funds vs a year ago

More buyers than sellers — 62% buying

Steady new buyers — ~31 new funds per quarter

Mostly new holders — 54% entered in last year

Growing discovery — still being found

Early stage — 93% of holders entered in last year

Smaller funds dominant — 13% AUM from top-100

Institutional Sentiment Summary — SION

Hedge Fund Ownership: SION

Market Analysis: SION

Analyst Price Targets

Analyst Recommendations

Stock Performance

Company Profile: SION

Is It Too Late to Buy SIONNA THERAPEUTICS INC (SION) Based on Hedge Fund 13F Filings?

Hedge Fund Positioning: SION

Statistics: SION

Valuation Measures Data as of: --

Financial Highlights

Institutional Holders (2026 Q1)

Frequently Asked Questions — SIONNA THERAPEUTICS INC (SION)

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