Stock Analysis
Data Source: SEC EDGAR 13F
Updated Hourly

VERTEX PHARMACEUTICALS INC (VRTX)

2K + Investors. Track Smart Money conviction in VRTX. See who's accumulating, reducing, or initiating positions.

Current Price
-- USD
Analyst Target
-- (0 analysts)
Upside
0.00%
Net Flow Q/Q
↑ +141
Streak
1Q ▲
Buyers last Q
56%

Smart Money Signals — VRTX

Based on 1552 hedge funds · latest filing: 2025 Q4 · updated quarterly

📈

Buying streak — 1 quarter in a row

last 6Q
For 1 consecutive quarter, more hedge funds added VRTX than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.
🏔️

At the ownership peak (100% of max)

100% of all-time peak
1,552 hedge funds hold VRTX right now — the highest count in 3.0 years. When ownership is this concentrated, any bad news can trigger a chain reaction: one big fund sells, others follow. This is a classic 'crowded trade' — high popularity doesn't equal safety.
📶

Steady growth — +7% more funds vs a year ago

fund count last 6Q
+107 new funds entered over the past year (+7% YoY). Gradual, steady growth in institutional ownership is generally a healthy signal — not a speculative rush, but consistent conviction.
🟡

Slight buying edge — 56% buying

840 buying657 selling
Last quarter: 840 funds bought or added vs 657 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.
📈

More new buyers each quarter (+111 vs last Q)

new funds entering per quarter
Funds opening a new VRTX position: 193 → 117 → 140 → 251. A growing influx of new institutional buyers means the asset is still gathering momentum — the consensus hasn't fully saturated yet.
🔒

66% of holders stayed for 2+ years

■ 66% conviction (2yr+) ■ 19% medium ■ 15% new
1,024 out of 1,552 hedge funds have held VRTX for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.
💰

Value +18% but shares only +2% — price-driven

Value
+18%
Shares
+1%
Last quarter: the total dollar value of institutional holdings rose +18%, but actual share count only changed +2%. The gap is explained by the stock's price rising — not new buying. Strong value growth with weak share growth means the rally is price momentum, not fresh institutional demand.
📈

Growing discovery — still being found

159 → 193 → 117 → 140 → 251 new funds/Q
New funds entering each quarter: 193 → 117 → 140 → 251. A growing number of institutions are discovering VRTX each quarter. The narrative is still spreading — leaving room for ongoing capital accumulation.
🏛️

Deep conviction — 66% of holders stayed 2+ years

■ 66% veterans ■ 14% 1-2yr ■ 19% new
Of 1,606 current holders: 1,066 (66%) have held for over 2 years without selling. These are not momentum buyers — they have lived through drawdowns and stayed. A large veteran base acts as a stabilizing force during selloffs.
🏆

Elite ownership — 67% AUM from top-100 funds

67% from top-100 AUM funds
47 of 1552 holders are among the 100 largest funds by AUM, controlling 67% of total institutional value in VRTX. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.
3.4
out of 10
Low Exit Risk
Exit risk score 3.4/10 — low institutional crowding. Ownership is below peak levels, holder base is relatively sticky, and buying momentum is positive.

Methodology note: these Smart Money cards use consecutive 13F disclosure snapshots, not trade-by-trade execution data. "Buying", "selling", "new holders", and "trimmed" refer to quarter-over-quarter changes in reported holders, aggregate shares, or disclosed position values between filings. They are useful for ownership regime analysis and crowding, but they do not imply exact trade timing on the filing date.

Hedge Fund Ownership: VRTX

How many hedge funds hold VRTX — quarterly history vs. share price
Quarterly hedge fund ownership of VRTX vs. share price

Market Analysis: VRTX

Analyst Price Targets

Avg. Price Target
--

Analyst Recommendations

Stock Performance

Real-time

Company Profile: VRTX

-- --

Institutional ownership data sourced from SEC EDGAR Form 13F-HR filings.

Smart Money Signal ?
Broad Consensus, Selective Conviction

Many quality funds hold this stock, but top-tier positions remain relatively small.

165 top-rated funds 20 high-conviction
Consensus
9.6
/ 10
breadth
×
Elite
4.7
/ 10
conviction
Hedge Fund Positioning: VRTX
2026 Q1 Stats Unlock in 11 days 2K + Investors

Track Smart Money conviction in VRTX. See who's accumulating, reducing, or initiating positions.

Metric All 13F Filers (2025 Q4) Prior (2025 Q3) Change
Funds Holding 1606 1466 9.55%
13F Shares 235M 231M 1.63%
Total Value $105.19B $88.94B 18.28%
New Positions 256 141 +115
Increased Positions 653 627 +26
Closed Positions 115 186 -71
Reduced Positions 631 634 -3
Total Calls 31 32 -3.12%
Total Puts 31 31 -
PUT/CALL Ratio 1.0 0.97 Neutral

Statistics: VRTX

View More

Valuation Measures Data as of: --

Market Cap --
Enterprise Value --
Trailing P/E --
Forward P/E --
PEG Ratio (5yr expected) --
Price/Sales (ttm) --
Price/Book (mrq) --
Enterprise Value/Revenue --
Enterprise Value/EBITDA --
Beta (5Y Monthly) --
Short Ratio (Days to Cover) --
Short % of Float --

Financial Highlights

Profitability
Profit Margin --
Return on Assets (ttm) --
Return on Equity (ttm) --
Income Statement & Cash Flow
Revenue (ttm) --
Net Income Avi to Common (ttm) --
Diluted EPS (ttm) --
Total Cash (mrq) --
Total Debt/Equity (mrq) --
Levered Free Cash Flow (ttm) --

Institutional Holders (2026 Q1)

2K + investors

Explore institutional interest and hedge fund ownership dynamics. Analyze portfolio weights, new positions, and conviction trends in VRTX. Verified SEC 13F-HR filings.

Top 25 institutional holders of VRTX — 2025 Q4 · Source: SEC Form 13F
# Investor % of Portfolio Shares Mkt Value
1 Andrew Hill Investment Advisors, Inc. 4.76% 11,955 $5.3M
2 Eurizon SLJ Capital Ltd 4.54% 21,523 $9.5M
3 Sivik Global Healthcare LLC 3.39% 10,000 $4K
4 NIA IMPACT ADVISORS, LLC 3.08% 15,490 $6.9M
5 Birch Hill Investment Advisors LLC 3.02% 150,795 $67.3M
6 BENDER ROBERT & ASSOCIATES 2.80% 26,171 $11.7M
7 Shelter Mutual Insurance Co 2.74% 27,600 $12.3M
8 AlphaCentric Advisors LLC 2.20% 4,931 $2.2M
9 Private Harbour Investment Management & Counsel, LLC 2.15% 4,383 $2.0M
10 B. Metzler seel. Sohn & Co. AG 2.12% 511,036 $228.2M
11 PUZO MICHAEL J 2.00% 15,414 $6.9M
12 Illumine Investment Management, LLC 1.98% 5,782 $2.6M
13 Graphene Investments SAS 1.98% 6,600 $2.9M
14 SOMERVILLE KURT F 1.97% 16,735 $7.5M
15 Heirloom Wealth Management 1.89% 23,458 $10.5M
16 CULLINAN ASSOCIATES INC 1.87% 51,762 $23.1M
17 Hemenway Trust Co LLC 1.85% 51,499 $23.0M
18 PRINCETON CAPITAL MANAGEMENT LLC 1.77% 14,531 $6.5M
19 FAGAN ASSOCIATES, INC. 1.65% 26,553 $11.9M
20 W.G. Shaheen & Associates DBA Whitney & Co 1.64% 44,117 $19.7M
21 Notis-McConarty Edward 1.61% 8,258 $3.5M
22 Fulcrum Capital LLC 1.60% 16,496 $7.4M
23 Boomfish Wealth Group, LLC 1.54% 6,463 $2.9M
24 Broderick Brian C 1.54% 18,656 $8.3M
25 DAVIDSON INVESTMENT ADVISORS 1.51% 62,883 $30.5M
Investor Ownership
History 		% of Portfolio Prev % Rank Conviction Avg Buy Price 13F Score™ 3Y / 7Y Sell Timing Shares Mkt Value Change Change % Source Quarter Filed

Frequently Asked Questions — VERTEX PHARMACEUTICALS INC (VRTX)

What does the Smart Money Trend signal show for VRTX?

Buying streak — 1 quarter in a row: For 1 consecutive quarter, more hedge funds added VRTX than sold it. That's a consistent pattern of professional buying — not a one-time trade. When institutions keep buying quarter after quarter, it usually means they see a multi-year opportunity, not just a short-term momentum flip.

What is the institutional breadth score for VRTX?

Slight buying edge — 56% buying: Last quarter: 840 funds bought or added vs 657 that reduced or exited. It's nearly a 50/50 split — some institutions are convinced, others are taking profits. This mixed picture is normal near price highs.

What is the fund quality score for VRTX holders?

Elite ownership — 67% AUM from top-100 funds: 47 of 1552 holders are among the 100 largest funds by AUM, controlling 67% of total institutional value in VRTX. When the biggest players dominate the cap table, it signifies deep institutional support — since mega-funds deploy the most rigorous due diligence and capital.

How long have hedge funds held VRTX?

66% of holders stayed for 2+ years: 1,024 out of 1,552 hedge funds have held VRTX for over 2 years without selling. Long-term investors are generally harder to shake out during market stress, creating a stable ownership base that limits the risk of sudden capitulation.

Where does this institutional ownership data come from?

All holdings data is sourced from SEC Form 13F filings, which institutional investment managers with over $100 million in assets are required to submit quarterly. Data is parsed directly from SEC EDGAR.

Disclaimer: The information on this page is for informational purposes only and does not constitute investment advice, a recommendation, or an offer to buy or sell any security. Institutional holdings data is sourced from SEC Form 13F filings and reflects positions as of the filing date. Past performance of any fund or portfolio is not indicative of future results. 13Foresight is not a registered investment adviser. Always conduct your own due diligence before making investment decisions.