ORBIMED ADVISORS LLC — 13F Holdings

2026 Q2  ·  154 Positions

2026 Q2 Portfolio Activity

In 2026 Q2, ORBIMED ADVISORS LLC maintained a portfolio of 154 distinct positions. The most significant new addition was UNITEDHEALTH GROUP INC, now representing 1.24% of the total fund value. They heavily accumulated shares in ELI LILLY & CO, increasing the position by 8.9%. Conversely, ORBIMED ADVISORS LLC completely exited their position in MDXHEALTH SA.
Position History hover any row below to update
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ORBIMED ADVISORS LLC New York, NY Hedge Fund / Asset Manager AUM $5,267M
PCA Score Concentration Risk
Risk ENB
Total Positions
154
Quarter
2026 Q2
Top Holding
EWTX (11.7%)
Top 10 Concentration
42.1%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-50 of 154

ORBIMED ADVISORS LLC Full Holdings List — 2026 Q2

Stock History Sector / Type Port % Prev % Rank / Prev Conviction
Freshness
Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
EWTX
EDGEWISE THERAP...
Healthcare 11.68% 9.69% #1
Prev: #1
7.0
no change no change
P
S
15,518,492 $630,516,330 2021 Q1 13F Filing 2026-06-30 2026-08-14
ELVN
ENLIVEN THERAPE...
Healthcare 6.37% 6.18% #2
Prev: #2
4.5
-1,182,906 -14.9%
P
S
6,776,632 $343,914,074 2023 Q1 13F Filing 2026-06-30 2026-08-14
LLY
ELI LILLY & CO
Healthcare 5.73% 4.32% #3 1
Prev: #4
5.3
21,100 8.9%
P
S
257,900 $309,332,997 2001 Q2 13F Filing 2026-06-30 2026-08-14
MBX
MBX BIOSCIENCES...
Healthcare 3.51% 2.15% #4 7
Prev: #11
2.4
-209,151 -5.7%
P
S
3,428,736 $189,266,227 2024 Q3 13F Filing 2026-06-30 2026-08-14
SVA
SINOVAC BIOTECH...
Unknown 3.42% 3.66% #5
Prev: #5
2.9
no change no change
P
S
2,718,735 $184,466,170 2011 Q4 13F Filing 2026-06-30 2026-08-14
AZNCF
ASTRAZENECA PLC
Unknown 3.17% 2.62% #6 3
Prev: #9
3.8
245,500 36.6%
P
S
915,700 $171,079,502 2026 Q1 13F Filing 2026-06-30 2026-08-14
GPCR
STRUCTURE THERA...
Healthcare 2.20% 1.41% #7 11
Prev: #18
3.4
733,997 49.7%
P
S
2,209,400 $118,578,498 2024 Q2 13F Filing 2026-06-30 2026-08-14
SION
SIONNA THERAPEU...
Healthcare 2.08% 2.81% #8
Prev: #8
0.8
-974,825 -27.6%
P
S
2,555,877 $112,433,029 2025 Q1 13F Filing 2026-06-30 2026-08-14
CRVS
CORVUS PHARMACE...
Healthcare 1.98% 2.08% #9 3
Prev: #12
1.8
no change no change
P
S
7,165,006 $107,045,190 2016 Q1 13F Filing 2026-06-30 2026-08-14
AVBP
ARRIVENT BIOPHA...
Healthcare 1.95% 1.38% #10 9
Prev: #19
1.8
no change no change
P
S
3,027,328 $105,169,375 2024 Q1 13F Filing 2026-06-30 2026-08-14
GH
GUARDANT HEALTH...
Healthcare 1.62% 0.80% #11 27
Prev: #38
3.1
148,500 34.1%
P
S
583,700 $87,572,511 2018 Q4 13F Filing 2026-06-30 2026-08-14
ARGX
ARGENX SE
Healthcare 1.60% 1.98% #12 1
Prev: #13
0.6
-44,020 -32.2%
P
S
92,880 $86,171,278 2017 Q2 13F Filing 2026-06-30 2026-08-14
MRK
MERCK & CO INC
Healthcare 1.58% 1.58% #13 4
Prev: #17
1.6
no change no change
P
S
663,400 $85,246,900 2003 Q3 13F Filing 2026-06-30 2026-08-14
QURE
UNIQURE NV
Healthcare 1.54% 0.69% #14 29
Prev: #43
1.1
-328,663 -15.4%
P
S
1,807,486 $83,252,805 2016 Q1 13F Filing 2026-06-30 2026-08-14
PRAX
PRAXIS PRECISIO...
Healthcare 1.43% 1.10% #15 12
Prev: #27
3.1
57,600 33.4%
P
S
230,100 $77,035,179 2024 Q1 13F Filing 2026-06-30 2026-08-14
EW
EDWARDS LIFESCI...
Healthcare 1.40% 1.95% #16 2
Prev: #14
0.6
-395,700 -32.2%
P
S
834,900 $75,525,054 2011 Q1 13F Filing 2026-06-30 2026-08-14
PRLD
PRELUDE THERAPE...
Healthcare 1.36% 0.74% #17 23
Prev: #40
3.0
2,815,315 25.8%
P
S
13,724,571 $73,151,963 2020 Q3 13F Filing 2026-06-30 2026-08-14
ABVX
ABIVAX SA
Healthcare 1.35% 1.03% #18 13
Prev: #31
2.5
80,822 17.4%
P
S
546,522 $72,829,522 2025 Q3 13F Filing 2026-06-30 2026-08-14
DYN
DYNE THERAPEUTI...
Healthcare 1.33% 1.05% #19 10
Prev: #29
2.5
317,800 10.9%
P
S
3,235,684 $71,864,542 2020 Q3 13F Filing 2026-06-30 2026-08-14
NTRA
NATERA INC
Healthcare 1.32% 1.04% #20 10
Prev: #30
1.5
no change no change
P
S
262,000 $71,119,900 2015 Q3 13F Filing 2026-06-30 2026-08-14
CGON
CG ONCOLOGY INC
Healthcare 1.28% 1.27% #21 1
Prev: #22
1.0
24,533 2.6%
P
S
972,800 $69,117,440 2024 Q3 13F Filing 2026-06-30 2026-08-14
UNH
UNITEDHEALTH GR...
Healthcare 1.24% #22
Prev: #—
4.0
161,100
NEW
161,100 $66,957,993 2009 Q2 13F Filing 2026-06-30 2026-08-14
SPRY
ARS PHARMACEUTI...
Healthcare 1.23% 1.32% #23 2
Prev: #21
1.5
no change no change
P
S
8,288,510 $66,390,965 2020 Q4 13F Filing 2026-06-30 2026-08-14
N/A
ASCENDIS PHARMA...
Unknown 1.21% #24
Prev: #—
4.0
244,456
NEW
244,456 $65,201,304 13F Filing 2026-06-30 2026-08-14
HUM
HUMANA INC
Healthcare 1.21% #25
Prev: #—
4.0
164,100
NEW
164,100 $65,183,802 2010 Q4 13F Filing 2026-06-30 2026-08-14
COGT
COGENT BIOSCIEN...
Healthcare 1.21% 0.25% #26 49
Prev: #75
3.5
1,359,200 422.0%
P
S
1,681,300 $65,066,310 2020 Q4 13F Filing 2026-06-30 2026-08-14
BSX
BOSTON SCIENTIF...
Healthcare 1.17% 2.96% #27 20
Prev: #7
0.5
-898,900 -37.7%
P
S
1,483,200 $63,302,976 2006 Q4 13F Filing 2026-06-30 2026-08-14
ISRG
INTUITIVE SURGI...
Healthcare 1.16% 1.91% #28 13
Prev: #15
0.5
-50,800 -24.3%
P
S
157,900 $62,793,672 2010 Q2 13F Filing 2026-06-30 2026-08-14
MLYS
MINERALYS THERA...
Healthcare 1.05% 1.10% #29 3
Prev: #26
0.9
57,400 2.8%
P
S
2,110,300 $56,935,894 2024 Q1 13F Filing 2026-06-30 2026-08-14
N/A
ODYSSEY THERAPE...
Unknown 1.04% #30
Prev: #—
3.9
3,001,198
NEW
3,001,198 $56,152,415 13F Filing 2026-06-30 2026-08-14
XENE
XENON PHARMACEU...
Healthcare 1.00% 1.22% #31 8
Prev: #23
0.9
-167,500 -15.8%
P
S
892,471 $53,869,550 2016 Q3 13F Filing 2026-06-30 2026-08-14
ARQT
ARCUTIS BIOTHER...
Healthcare 0.99% #32
Prev: #—
3.9
2,042,000
NEW
2,042,000 $53,541,240 2020 Q1 13F Filing 2026-06-30 2026-08-14
BMY
BRISTOL-MYERS S...
Healthcare 0.99% 1.11% #33 8
Prev: #25
1.4
no change no change
P
S
925,000 $53,298,500 2007 Q2 13F Filing 2026-06-30 2026-08-14
QTTB
Q32 BIO INC
Healthcare 0.97% 0.29% #34 32
Prev: #66
3.4
1,875,000 83.2%
P
S
4,127,987 $52,590,554 2024 Q1 13F Filing 2026-06-30 2026-08-14
SYK
STRYKER CORPORA...
Healthcare 0.93% 1.19% #35 11
Prev: #24
0.9
-23,400 -12.8%
P
S
159,100 $50,091,044 2006 Q4 13F Filing 2026-06-30 2026-08-14
CAI
CARIS LIFE SCIE...
Healthcare 0.93% 0.99% #36 2
Prev: #34
1.4
no change no change
P
S
2,806,811 $50,017,372 2025 Q2 13F Filing 2026-06-30 2026-08-14
XBI
SPDR SERIES TRU...
PUT
PUT Option 0.88% #37
Prev: #—
3.9
300,000
NEW
300,000 $47,475,000 2013 Q2 13F Filing 2026-06-30 2026-08-14
TMO
THERMO FISHER S...
Healthcare 0.84% 0.45% #38 14
Prev: #52
3.3
44,200 95.1%
P
S
90,700 $45,473,352 2006 Q4 13F Filing 2026-06-30 2026-08-14
PVLA
PALVELLA THERAP...
Healthcare 0.83% 0.33% #39 22
Prev: #61
3.3
157,760 117.2%
P
S
292,360 $44,678,455 2026 Q1 13F Filing 2026-06-30 2026-08-14
ELV
ELEVANCE HEALTH...
Healthcare 0.82% 0.67% #40 5
Prev: #45
1.3
no change no change
P
S
114,700 $44,357,931 2014 Q4 13F Filing 2026-06-30 2026-08-14
STTK
SHATTUCK LABS I...
Healthcare 0.81% 0.80% #41 4
Prev: #37
1.3
no change no change
P
S
6,306,127 $43,764,521 2025 Q3 13F Filing 2026-06-30 2026-08-14
UPB
UPSTREAM BIO IN...
Healthcare 0.73% 1.02% #42 10
Prev: #32
1.3
no change no change
P
S
5,693,589 $39,399,636 2024 Q4 13F Filing 2026-06-30 2026-08-14
CRNX
CRINETICS PHARM...
Healthcare 0.69% 0.72% #43 2
Prev: #41
1.3
no change no change
P
S
999,000 $37,382,580 2018 Q3 13F Filing 2026-06-30 2026-08-14
RYTM
RHYTHM PHARMACE...
Healthcare 0.66% 0.54% #44 7
Prev: #51
0.8
8,800 2.8%
P
S
322,900 $35,851,587 2017 Q4 13F Filing 2026-06-30 2026-08-14
SNDX
SYNDAX PHARMACE...
Healthcare 0.62% 0.45% #45 8
Prev: #53
3.2
579,700 60.2%
P
S
1,542,000 $33,708,120 2016 Q1 13F Filing 2026-06-30 2026-08-14
FBRX
FORTE BIOSCIENC...
Healthcare 0.62% 0.61% #46 1
Prev: #47
2.7
380,750 31.8%
P
S
1,577,705 $33,526,231 2024 Q4 13F Filing 2026-06-30 2026-08-14
CMPX
COMPASS THERAPE...
Healthcare 0.62% 1.60% #47 31
Prev: #16
1.2
no change no change
P
S
15,219,994 $33,331,787 2021 Q4 13F Filing 2026-06-30 2026-08-14
NKTR
NEKTAR THERAPEU...
Healthcare 0.60% 0.39% #48 10
Prev: #58
3.2
190,346 69.2%
P
S
465,346 $32,485,804 2005 Q1 13F Filing 2026-06-30 2026-08-14
KRYS
KRYSTAL BIOTECH...
Healthcare 0.57% 0.35% #49 11
Prev: #60
2.7
14,100 20.4%
P
S
83,200 $30,922,944 2019 Q1 13F Filing 2026-06-30 2026-08-14
N/A
PRELUDE THERAPE...
Unknown 0.56% 0.44% #50 4
Prev: #54
0.7
-530,713 -8.5%
P
S
5,680,186 $30,275,391 13F Filing 2026-06-30 2026-08-14
Showing 1-50 of 154 holdings

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