RTW INVESTMENTS, LP — 13F Holdings

2026 Q2  ·  97 Positions

2026 Q2 Portfolio Activity

In 2026 Q2, RTW INVESTMENTS, LP maintained a portfolio of 97 distinct positions. The most significant new addition was STRUCTURE THERAPEUTICS INC, now representing 0.74% of the total fund value. They heavily accumulated shares in KAILERA THERAPEUTICS INC, increasing the position by 2790.3%. Conversely, RTW INVESTMENTS, LP completely exited their position in APOGEE THERAPEUTICS INC.
Position History hover any row below to update
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RTW INVESTMENTS, LP New York, NY Hedge Fund AUM $11,713M
PCA Score Concentration Risk
Risk ENB
Total Positions
97
Quarter
2026 Q2
Top Holding
MDGL (9.1%)
Top 10 Concentration
47.7%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-50 of 97

RTW INVESTMENTS, LP Full Holdings List — 2026 Q2

Stock History Sector / Type Port % Prev % Rank / Prev Conviction
Freshness
Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
MDGL
MADRIGAL PHARMA...
Healthcare 9.14% 10.38% #1
Prev: #1
6.7
no change no change
P
S
1,993,687 $1,070,510,235 2023 Q2 13F Filing 2026-06-30 2026-08-14
ARGX
ARGENX SE
Healthcare 5.62% 5.16% #2 3
Prev: #5
4.7
no change no change
P
S
709,446 $658,202,715 2017 Q2 13F Filing 2026-06-30 2026-08-14
PTCT
PTC THERAPEUTIC...
Healthcare 5.39% 5.25% #3 1
Prev: #4
4.2
no change no change
P
S
7,746,415 $631,875,072 2016 Q4 13F Filing 2026-06-30 2026-08-14
PTGX
PROTAGONIST THE...
Healthcare 5.30% 5.31% #4 1
Prev: #3
3.1
2,122 0.0%
P
S
5,061,175 $620,398,832 2019 Q3 13F Filing 2026-06-30 2026-08-14
CGON
CG ONCOLOGY INC
Healthcare 5.16% 4.70% #5 1
Prev: #6
5.1
1,529,782 21.9%
P
S
8,514,590 $604,961,620 2024 Q1 13F Filing 2026-06-30 2026-08-14
INSM
INSMED INC
Healthcare 4.41% 7.88% #6 4
Prev: #2
2.8
no change no change
P
S
4,842,880 $516,347,866 2023 Q2 13F Filing 2026-06-30 2026-08-14
TNGX
TANGO THERAPEUT...
Healthcare 3.71% 2.77% #7 1
Prev: #8
2.0
600,000 4.5%
P
S
13,900,620 $434,533,381 2021 Q3 13F Filing 2026-06-30 2026-08-14
SYRE
SPYRE THERAPEUT...
Healthcare 3.22% 2.09% #8 6
Prev: #14
1.8
80,000 1.9%
P
S
4,251,996 $377,492,205 2023 Q4 13F Filing 2026-06-30 2026-08-14
CELC
CELCUITY INC
Healthcare 2.95% 3.45% #9 2
Prev: #7
3.2
265,282 8.7%
P
S
3,304,903 $345,758,952 2025 Q4 13F Filing 2026-06-30 2026-08-14
ERAS
ERASCA INC
Healthcare 2.81% 2.60% #10 1
Prev: #9
3.1
1,789,579 11.1%
P
S
17,946,754 $328,784,533 2025 Q4 13F Filing 2026-06-30 2026-08-14
RDNT
RADNET INC
Healthcare 2.55% 2.38% #11
Prev: #11
3.0
561,958 13.1%
P
S
4,846,958 $298,911,900 2023 Q4 13F Filing 2026-06-30 2026-08-14
ORKA
ORUKA THERAPEUT...
Healthcare 2.55% 1.00% #12 18
Prev: #30
4.0
1,080,882 52.5%
P
S
3,139,030 $298,741,485 2024 Q3 13F Filing 2026-06-30 2026-08-14
NTRA
NATERA INC
Healthcare 2.32% 2.49% #13 3
Prev: #10
0.9
-250,000 -20.0%
P
S
1,000,000 $271,450,000 2015 Q3 13F Filing 2026-06-30 2026-08-14
RARE
ULTRAGENYX PHAR...
Healthcare 2.22% 0.76% #14 22
Prev: #36
3.9
4,148,100 113.7%
P
S
7,796,895 $260,338,324 2021 Q4 13F Filing 2026-06-30 2026-08-14
IRTC
IRHYTHM HOLDING...
Healthcare 2.22% 1.96% #15 1
Prev: #16
3.4
514,131 30.8%
P
S
2,182,631 $259,623,957 2025 Q4 13F Filing 2026-06-30 2026-08-14
CYTK
CYTOKINETICS IN...
Healthcare 2.08% 1.78% #16 2
Prev: #18
2.8
140,845 5.2%
P
S
2,862,003 $243,814,036 2020 Q3 13F Filing 2026-06-30 2026-08-14
N/A
KAILERA THERAPE...
Unknown 2.03% #17
Prev: #—
4.3
10,776,820
NEW
10,776,820 $237,413,345 13F Filing 2026-06-30 2026-08-14
ESTA
ESTABLISHMENT L...
Healthcare 1.95% 1.50% #18 2
Prev: #20
1.8
no change no change
P
S
2,655,695 $227,885,188 2018 Q3 13F Filing 2026-06-30 2026-08-14
GH
GUARDANT HEALTH...
Healthcare 1.90% 1.36% #19 6
Prev: #25
1.8
no change no change
P
S
1,481,033 $222,199,381 2020 Q3 13F Filing 2026-06-30 2026-08-14
NBIX
NEUROCRINE BIOS...
Healthcare 1.82% 1.39% #20 4
Prev: #24
2.7
205,853 19.4%
P
S
1,267,925 $213,689,740 2025 Q2 13F Filing 2026-06-30 2026-08-14
TARS
TARSUS PHARMACE...
Healthcare 1.80% 2.34% #21 9
Prev: #12
1.2
11,034 0.3%
P
S
3,357,059 $211,293,293 2020 Q4 13F Filing 2026-06-30 2026-08-14
STOK
STOKE THERAPEUT...
Healthcare 1.57% 1.82% #22 5
Prev: #17
1.6
no change no change
P
S
5,623,525 $184,001,738 2019 Q2 13F Filing 2026-06-30 2026-08-14
QURE
UNIQURE NV
Healthcare 1.55% 0.42% #23 23
Prev: #46
3.6
1,355,216 52.4%
P
S
3,941,572 $181,548,806 2017 Q4 13F Filing 2026-06-30 2026-08-14
ACAD
ACADIA PHARMACE...
Healthcare 1.54% 1.58% #24 5
Prev: #19
1.6
no change no change
P
S
7,144,524 $180,756,457 2022 Q2 13F Filing 2026-06-30 2026-08-14
RGEN
REPLIGEN CORP
Healthcare 1.45% 1.41% #25 2
Prev: #23
1.1
34,637 2.9%
P
S
1,240,637 $169,272,512 2025 Q4 13F Filing 2026-06-30 2026-08-14
URGN
UROGEN PHARMA L...
Healthcare 1.43% 0.81% #26 7
Prev: #33
1.6
no change no change
P
S
4,543,895 $167,215,336 2021 Q3 13F Filing 2026-06-30 2026-08-14
GHRS
GH RESEARCH PLC
Healthcare 1.36% 0.83% #27 4
Prev: #31
1.5
no change no change
P
S
5,933,815 $159,500,947 2021 Q2 13F Filing 2026-06-30 2026-08-14
IMCR
IMMUNOCORE HLDG...
Healthcare 1.32% 1.46% #28 6
Prev: #22
1.5
no change no change
P
S
4,869,798 $154,616,087 2021 Q1 13F Filing 2026-06-30 2026-08-14
CMPS
COMPASS PATHWAY...
Healthcare 1.29% 0.59% #29 13
Prev: #42
1.0
68,584 0.6%
P
S
10,700,974 $151,418,782 2024 Q4 13F Filing 2026-06-30 2026-08-14
IMTX
IMMATICS N.V
Healthcare 1.12% 1.26% #30 4
Prev: #26
0.9
76,836 0.6%
P
S
12,946,176 $131,144,763 2020 Q3 13F Filing 2026-06-30 2026-08-14
ZLAB
ZAI LAB LTD
Healthcare 1.07% 1.23% #31 4
Prev: #27
1.4
no change no change
P
S
6,574,032 $124,906,608 2024 Q4 13F Filing 2026-06-30 2026-08-14
IMVT
IMMUNOVANT INC
Healthcare 1.05% 0.79% #32 3
Prev: #35
1.4
no change no change
P
S
3,177,849 $122,442,522 2019 Q4 13F Filing 2026-06-30 2026-08-14
BLTE
BELITE BIO INC
Healthcare 0.94% 1.13% #33 5
Prev: #28
1.4
no change no change
P
S
715,332 $110,150,398 2025 Q3 13F Filing 2026-06-30 2026-08-14
XNCR
XENCOR INC
Healthcare 0.93% 0.81% #34 2
Prev: #32
1.4
no change no change
P
S
6,777,461 $109,117,122 2024 Q3 13F Filing 2026-06-30 2026-08-14
TSHA
TAYSHA GENE THE...
Healthcare 0.79% 0.61% #35 5
Prev: #40
0.8
-119,990 -0.9%
P
S
13,560,258 $92,345,357 2023 Q3 13F Filing 2026-06-30 2026-08-14
COGT
COGENT BIOSCIEN...
Healthcare 0.76% 2.09% #36 21
Prev: #15
0.3
-3,149,654 -57.7%
P
S
2,309,021 $89,359,113 2025 Q3 13F Filing 2026-06-30 2026-08-14
ALKS
ALKERMES PLC
Healthcare 0.75% 0.59% #37 4
Prev: #41
1.3
no change no change
P
S
1,672,356 $87,623,093 2023 Q3 13F Filing 2026-06-30 2026-08-14
GPCR
STRUCTURE THERA...
Healthcare 0.74% #38
Prev: #—
3.8
1,607,507
NEW
1,607,507 $86,274,901 2024 Q2 13F Filing 2026-06-30 2026-08-14
REPL
REPLIMUNE GROUP...
Healthcare 0.70% 0.56% #39 5
Prev: #44
0.8
54,665 0.7%
P
S
7,411,581 $82,046,202 2024 Q2 13F Filing 2026-06-30 2026-08-14
CSTL
CASTLE BIOSCIEN...
Healthcare 0.57% 0.67% #40 2
Prev: #38
0.7
20,000 0.7%
P
S
2,778,335 $66,263,290 2019 Q3 13F Filing 2026-06-30 2026-08-14
CADL
CANDEL THERAPEU...
Healthcare 0.56% 0.31% #41 13
Prev: #54
1.2
no change no change
P
S
6,422,018 $66,146,785 2026 Q1 13F Filing 2026-06-30 2026-08-14
RCKT
ROCKET PHARMACE...
Healthcare 0.52% 0.63% #42 3
Prev: #39
1.2
no change no change
P
S
17,687,772 $60,492,180 2018 Q1 13F Filing 2026-06-30 2026-08-14
KOD
KODIAK SCIENCES...
Healthcare 0.49% 0.56% #43
Prev: #43
1.2
no change no change
P
S
1,487,934 $57,969,909 2025 Q4 13F Filing 2026-06-30 2026-08-14
N/A
AKTIS ONCOLOGY ...
Unknown 0.44% 0.28% #44 12
Prev: #56
1.2
no change no change
P
S
1,592,043 $51,311,546 13F Filing 2026-06-30 2026-08-14
AXGN
AXOGEN INC
Healthcare 0.40% #45
Prev: #—
3.7
1,011,576
NEW
1,011,576 $46,724,695 2026 Q2 13F Filing 2026-06-30 2026-08-14
DHR
DANAHER CORP DE...
Healthcare 0.37% #46
Prev: #—
3.6
230,000
NEW
230,000 $43,810,400 2023 Q4 13F Filing 2026-06-30 2026-08-14
CGEM
CULLINAN THERAP...
Healthcare 0.37% 0.24% #47 11
Prev: #58
2.6
658,387 38.6%
P
S
2,364,347 $43,054,759 2024 Q2 13F Filing 2026-06-30 2026-08-14
NGNE
NEUROGENE INC
Healthcare 0.37% 0.27% #48 9
Prev: #57
1.1
no change no change
P
S
1,362,456 $42,849,241 2024 Q1 13F Filing 2026-06-30 2026-08-14
HNGE
HINGE HEALTH IN...
Healthcare 0.35% 0.74% #49 12
Prev: #37
0.1
-1,430,000 -74.1%
P
S
500,000 $41,500,000 2025 Q4 13F Filing 2026-06-30 2026-08-14
OBIO
ORCHESTRA BIOME...
Healthcare 0.35% 0.35% #50 1
Prev: #49
2.1
1,250,000 15.0%
P
S
9,556,063 $41,234,412 2023 Q1 13F Filing 2026-06-30 2026-08-14
Showing 1-50 of 97 holdings

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