SR ONE CAPITAL MANAGEMENT, LP — 13F Holdings

2026 Q1  ·  14 Positions

2026 Q1 Portfolio Activity

In 2026 Q1, SR ONE CAPITAL MANAGEMENT, LP maintained a portfolio of 14 distinct positions. The most significant new addition was Veradermics, Inc., now representing 16.57% of the total fund value.
Position History hover any row below to update
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SR ONE CAPITAL MANAGEMENT, LP Conshohocken, PA Hedge Fund / Life Sciences Specialist AUM $915M
PCA Score Concentration Risk
Risk ENB
Total Positions
14
Quarter
2026 Q1
Top Holding
ACLX (29.4%)
Top 10 Concentration
96.5%
Turnover Rate
23.4%
Sector HHI
0.18
Items per page:
Showing 1-14 of 14

SR ONE CAPITAL MANAGEMENT, LP Full Holdings List — 2026 Q1

Stock History Sector / Type Port % Prev % Rank / Prev Conviction
Freshness
Change % Change Influence Shares Mkt Value Avg Cost Price Held 1st Owned Source Source Date Date Reported
ACLX
Arcellx, Inc.
Healthcare 29.43% 21.66% #1 1
Prev: #2
7.0
no change no change
P
S
2,346,630 $269,440,057 2022 Q1 13F Filing 2026-03-31 2026-05-14
N/A
Veradermics, In...
Unknown 16.57% #2
Prev: #—
9.0
2,401,868
NEW
2,401,868 $151,677,964 13F Filing 2026-03-31 2026-05-14
ZBIO
Zenas BioPharma...
Healthcare 10.76% 25.90% #3 2
Prev: #1
6.0
no change no change
P
S
5,037,854 $98,490,046 2024 Q3 13F Filing 2026-03-31 2026-05-14
CRSP
CRISPR Therapeu...
Healthcare 10.59% 15.14% #4 1
Prev: #3
5.5
no change no change
P
S
2,038,763 $96,983,956 2024 Q1 13F Filing 2026-03-31 2026-05-14
DSGN
Design Therapeu...
Healthcare 7.59% 8.67% #5 1
Prev: #4
4.5
no change no change
P
S
6,526,476 $69,441,704 2021 Q4 13F Filing 2026-03-31 2026-05-14
ORIC
ORIC Pharmaceut...
Healthcare 6.39% 5.34% #6 1
Prev: #7
3.6
no change no change
P
S
4,514,929 $58,476,915 2025 Q2 13F Filing 2026-03-31 2026-05-14
ALMS
Alumis Inc.
Healthcare 4.72% 2.71% #7 1
Prev: #8
2.9
no change no change
P
S
1,959,896 $43,176,509 2024 Q2 13F Filing 2026-03-31 2026-05-14
MLYS
Mineralys Thera...
Healthcare 4.63% 8.03% #8 3
Prev: #5
2.9
no change no change
P
S
1,563,966 $42,367,839 2023 Q2 13F Filing 2026-03-31 2026-05-14
SPRY
ARS Pharmaceuti...
Healthcare 3.52% 6.62% #9 3
Prev: #6
2.4
no change no change
P
S
4,012,903 $32,223,611 2022 Q4 13F Filing 2026-03-31 2026-05-14
ORKA
Oruka Therapeut...
Healthcare 2.31% 1.85% #10 1
Prev: #9
1.9
no change no change
P
S
430,330 $21,107,686 2024 Q3 13F Filing 2026-03-31 2026-05-14
OCS
Oculis Holding ...
Healthcare 1.86% 1.81% #11 1
Prev: #10
1.7
no change no change
P
S
641,022 $17,044,775 2025 Q1 13F Filing 2026-03-31 2026-05-14
NKTX
Nkarta, Inc.
Healthcare 0.77% 0.87% #12
Prev: #12
1.3
no change no change
P
S
3,333,333 $7,033,333 2022 Q2 13F Filing 2026-03-31 2026-05-14
ENGN
enGene Holdings...
Healthcare 0.56% 0.96% #13 2
Prev: #11
1.2
no change no change
P
S
747,750 $5,092,178 2024 Q2 13F Filing 2026-03-31 2026-05-14
RARE
Ultragenyx Phar...
Healthcare 0.32% 0.45% #14 1
Prev: #13
1.1
no change no change
P
S
137,753 $2,885,925 2025 Q4 13F Filing 2026-03-31 2026-05-14
Showing 1-14 of 14 holdings

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